The microcapsules associated with Nurse Call Systems Sydney can be incorporated in tablets or caspules: in this way controlled-release pharmaceutical forms are obtained, that is, capable of releasing the active principle in specifically designed ways. The animation on the left shows the progressive dissolution of the various layers that make up a multi-layer capsule containing microcapsules.
Some options are programmed release theophylline intended for the treatment of bronchial asthma, chronic and indeterminate bronchitis, pulmonary emphysema. The programmed action of theophylline release is due to a two-stage release system, made with a hydrophilic matrix of acetophthalate cellulose in which numerous small nuclei are dispersed.
The hydrophilic matrix ensures a release of theophylline in the first hours after administration; the nuclei, made up of an inert microcapsule that provides support to some layers of theophylline separated by a particular membrane, which lets water pass freely but slows down the release of the theophylline molecules, ensuring a continuous and constant release, whose kinetics of pseudo zero order allows to maintain stable (in the optimal therapeutic range) for about 24 hi theophylline blood levels. In this way it is possible, by administering the drug twice a day, to provide one effective protection from bronchospasm, both during the day and at night.
It is a pharmaceutical preparation linked to Nurse Call Systems Sydney of acetylsalicylic acid with a protracted action. Each tablet is made up of microgranules coated with a very thin ethylcellulose membrane, neutral and non-toxic, which is not dissolved and digested in the gastro-enteric tract, but which allows a gradual release of acetylsalicylic acid, in close correlation with the progressive increase in environmental pH.
This formulation is absorbed more slowly and regularly than the uncoated acid, thus ensuring a more constant and prolonged concentration of the drug in the blood for at least 8-12 h. Compared to acetylsalicylic acid in traditional tablets, it has the advantage of better tolerability: after the disaggregation of the pharmaceutical form, the millions of microcapsules dispersed on the stomach mucosa cause the irritative phenomena typical of uncoated particles to be reduced.
The process was applied to encapsulate vitamins, mineral salts and dietary products. Food ingredients can be coated to mask unwanted aromas or improve stability. Thin coatings are very effective in reducing the scale of certain materials. Extractive substances: extractive components may require a coating to optimize the stability of an ingredient or product. The release properties of the ingredients can be optimized with health benefits.
pet food: nutrients, medicines and other additives can be coated to mask odors and improve animal acceptability. Medicines can be stabilized by the protective coating which can also be studied to delay release after ingestion.